Tamsulosin hydrochloride ( LY253351; YM-12617-1 )

Catalog No. M10281 CAS No. 106463-17-6

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Product Name

Tamsulosin hydrochloride
Note

Research use only, not for human use.
Brief Description

Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck.
Description

Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.
Synonyms

LY253351; YM-12617-1
Pathway

Endocrinology/Hormones
Target

Adrenergic Receptor
Recptor

α1A-adrenergic receptor; α1B-adrenergic receptor; α1D-adrenergic receptor
Research Area

Neurological Disease
Indication

——

CAS Number

106463-17-6
Formula Weight

444.97
Molecular Formula

C20H29ClN2O5S
Purity

>98%(HPLC)
Solubility

Water: 215.9 mg/L
SMILES

O=S(C1=CC=C(C[C@H](NCCOC2=CC=CC=C2OCC)C)C=C1)(N)=O.[H]Cl
Chemical Name

5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-benzenesulfonamide hydrochloride

1.Abrams P, et al. Br J Urol. 1997 Oct; 80(4):587-96.

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